Publications in Nature 2023 : a new drug prevents EMT, metastasis and resistance to anti-cancer therapy

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Pharmacological targeting of netrin-1 inhibits EMT in cancer.
Lengrand J, Pastushenko I, Vanuytven S, Song Y, Venet D, Sarate RM, Bellina M, Moers V, Boinet A, Sifrim A, Rama N, Ducarouge B, Van Herck J, Dubois C, Scozzaro S, Lemaire S, Gieskes S, Bonni S, Collin A, Braissand N, Allard J, Zindy E, Decaestecker C, Sotiriou C, Salmon I, Mehlen P, Voet T, Bernet A, Blanpain C.
Nature. 2023 Aug 2. doi: 10.1038/s41586-023-06372-2.
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Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer.
Cassier PA, Navaridas R, Bellina M, Rama N, Ducarouge B, Hernandez-Vargas H, Delord JP, Lengrand J, Paradisi A, Fattet L, Garin G, Gheit H, Dalban C, Pastushenko I, Neves D, Jelin R, Gadot N, Braissand N, Léon S, Degletagne C, Matias-Guiu X, Devouassoux-Shisheboran M, Mery-Lamarche E, Allard J, Zindy E, Decaestecker C, Salmon I, Perol D, Dolcet X, Ray-Coquard I,Blanpain C*, Bernet A*, Mehlen P* (*last co-authors)
Nature. 2023 Aug 2. doi: 10.1038/s41586-023-06367-z.
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Publication in Nature 2023 : RHOJ controls EMT-associated resistance to chemotherapy

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RHOJ controls EMT-associated resistance to chemotherapy.
Debaugnies M, Rodriguez-Acebes S, Blondeau J, Parent MA, Zocco M, Song Y, Latil M, Dubois C, Moers M, Impens F, Van Haver D, Rorive S, Allard J, Uemura A, Sotiropoulou PA, Salmon I, Méndez J, Blanpain C.
Nature 2023. https://doi.org/10.1038/s41586-023-05838-7
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Yura Song at the Young scientist special session

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Yura Song (PhD student in bioinformatics), was selected to be one of the twelve speakers of the Young scientist special session, which was co-organized by Stanford University, K-bioX (a non-profit organization of Korean scientists in USA), Department of Pharmacy – Seoul National University, College of Medicine – Catholic university of Korea, College of Medicine – Chungang University (all are located in Seoul, Korea)​.  She got third prize with the paper “NR2F2 controls malignant squamous cell carcinoma state by promoting stemness and invasion and repressing differentiation“. Federico Mauri, Corentin Schepkens,…and Cédric Blanpain. Nature Cancer, volume 2, pages 1152–1169 (2021).

Publication in Nature Cell Biology 2022 : Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors

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Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors.
Lin X, Swedlund B, Ton MN, Ghazanfar S, Guibentif C, Paulissen C, Baudelet E, Plaindoux E, Achouri Y, Calonne E, Dubois C, Mansfield W, Zaffran S, Marioni JC, Fuks F, Göttgens B, Lescroart F, Blanpain C.
Nat Cell Biol. 2022 Jul;24(7):1114-1128. doi: 10.1038/s41556-022-00947-3. Epub 2022 Jul 11.PMID: 35817961
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Spanish Order of Civil Merit awarded to the lab

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On June 16, H.E. Ambassador of Spain in Belgium awarded the laboratory the Orden del Mérito Civil (Order of Civil Merit).  She wanted to highlight the discoveries made by the laboratory on the Fat1 gene, thanks to the collaboration with many Spanish hospitals.