Dynamic regulation of tissue fluidity controls skin repair during wound healing.
Sarate RM, Hochstetter J, Valet M, Hallou A, Song Y, Bansaccal N, Ligare M, Aragona M, Engelman D, Bauduin A, Campàs O, Simons BD, Blanpain C.
Cell. 2024 Aug 11:S0092-8674(24)00825-0. doi: 10.1016/j.cell.2024.07.031. Online ahead of print.
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Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment.
Giafaglione JM, Crowell PD, Delcourt AML, Hashimoto T, Ha SM, Atmakuri A, Nunley NM, Dang RMA, Tian M, Diaz JA, Tika E, Payne MC, Burkhart DL, Li D, Navone NM, Corey E, Nelson PS, Lin NYC, Blanpain C, Ellis L, Boutros PC, Goldstein AS.
Nat Cell Biol. 2023 Dec;25(12):1821-1832. doi: 10.1038/s41556-023-01274-x. Epub 2023 Dec 4.
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The extracellular matrix dictates regional competence for tumour initiation.
Nature. 2023 Nov;623(7988):828-835. doi: 10.1038/s41586-023-06740-y. Epub 2023 Nov 15.
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Modeling the complexity of mammary gland in vitro.
Nat Methods. 2023 Nov 2. doi: 10.1038/s41592-023-02064-x.
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Mammary duct luminal epithelium controls adipocyte thermogenic programme.
Patel S, Sparman NZR, Arneson D, Alvarsson A, Santos LC, Duesman SJ, Centonze A, Hathaway E, Ahn IS, Diamante G, Cely I, Cho CH, Talari NK, Rajbhandari AK, Goedeke L, Wang P, Butte AJ, Blanpain C, Chella Krishnan K, Lusis AJ, Stanley SA, Yang X, Rajbhandari P.
Nature. 2023 Aug;620(7972):192-199. doi: 10.1038/s41586-023-06361-5.
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Cancer cell plasticity during tumour progression, metastasis and response to therapy.
Pérez-González A, Bévant K, Blanpain C.
Nat Cancer. 2023 Aug;4(8):1063-1082. doi: 10.1038/s43018-023-00595-y. Epub 2023 Aug 3. Review.
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Pharmacological targeting of netrin-1 inhibits EMT in cancer.
Lengrand J, Pastushenko I, Vanuytven S, Song Y, Venet D, Sarate RM, Bellina M, Moers V, Boinet A, Sifrim A, Rama N, Ducarouge B, Van Herck J, Dubois C, Scozzaro S, Lemaire S, Gieskes S, Bonni S, Collin A, Braissand N, Allard J, Zindy E, Decaestecker C, Sotiriou C, Salmon I, Mehlen P, Voet T, Bernet A, Blanpain C.
Nature. 2023 Aug;620(7973):402-408. doi: 10.1038/s41586-023-06372-2. Epub 2023 Aug 2.
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Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer.
Cassier PA, Navaridas R, Bellina M, Rama N, Ducarouge B, Hernandez-Vargas H, Delord JP, Lengrand J, Paradisi A, Fattet L, Garin G, Gheit H, Dalban C, Pastushenko I, Neves D, Jelin R, Gadot N, Braissand N, Léon S, Degletagne C, Matias-Guiu X, Devouassoux-Shisheboran M, Mery-Lamarche E, Allard J, Zindy E, Decaestecker C, Salmon I, Perol D, Dolcet X, Ray-Coquard I,Blanpain C*, Bernet A*, Mehlen P* (*last co-authors)
Nature. 2023 Aug;620(7973):409-416. doi: 10.1038/s41586-023-06367-z. Epub 2023 Aug 2.
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Cell type and stage specific transcriptional, chromatin and cell-cell communication landscapes in the mammary gland.
Song Y, Fioramonti M, Bouvencourt G, Dubois C, Blanpain C, Van Keymeulen A.
Heliyon. 2023 Jun 30;9(7):e17842. doi: 10.1016/j.heliyon.2023.e17842.
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RHOJ controls EMT-associated resistance to chemotherapy.
Debaugnies M, Rodriguez-Acebes S, Blondeau J, Parent MA, Zocco M, Song Y, Latil M, Dubois C, Moers M, Impens F, Van Haver D, Rorive S, Allard J, Uemura A, Sotiropoulou PA, Salmon I, Méndez J, Blanpain C.
Nature. 2023 Apr;616(7955):168-175. doi: 10.1038/s41586-023-05838-7.
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A cellular hierarchy in melanoma uncouples growth and metastasis.
Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors.
Nat Cell Biol. 2022 Jul;24(7):1114-1128. doi: 10.1038/s41556-022-00947-3. Epub 2022 Jul 11.
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Prostate luminal progenitor cells: from mouse to human, from health to disease.
Baures M, Dariane C, Tika E, Puig Lombardi E, Barry Delongchamps N, Blanpain C, Guidotti JE, Goffin V.
Nat Rev Urol. 2022 Apr;19(4):201-218. doi: 10.1038/s41585-021-00561-2. Epub 2022 Jan 25.PMID: 35079142 Review.
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Deciphering functional tumor states at single-cell resolution.
EMBO J. 2021 Dec 17:e109221. doi: 10.15252/embj.2021109221. Review.
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NR2F2 controls malignant squamous cell carcinoma state by promoting stemness and invasion and repressing differentiation
Mauri M, Schepkens C, Lapouge G, Drogat B, Song Y, Pastushenko I, Rorive S, Blondeau J, Golstein S, Bareche Y, Miglianico M, Nkusi E, Rozzi M, Moers M, Brisebarre A, Raphael M, Dubois C, Allard J, Durdu B, Ribeiro F, Sotiriou C, Salmon I, Vakili J & Blanpain C
Nature Cancer. 2021 Nov;2(11):1152–1169. doi: 10.1038/s43018-021-00287-5
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Tristetraprolin expression by keratinocytes protects against skin carcinogenesis.
JCI Insight. 2021 Mar 8;6(5):e140669. doi: 10.1172/jci.insight.140669.
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Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis.
Nature. 2021 Jan;589(7842):448-455. doi: 10.1038/s41586-020-03046-1. Epub 2020 Dec 16.
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Targeting the epigenetic addiction of Merkel cell carcinoma.
Mauri F, Blanpain C.
EMBO Mol Med. 2020 Oct 16:e13347. doi: 10.15252/emmm.202013347. Online ahead of print.
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Recording EMT Activity by Lineage Tracing during Metastasis.
Vieugué P, Blanpain C.
Dev Cell. 2020 Sep 14;54(5):567-569. doi: 10.1016/j.devcel.2020.07.011.
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Heterotypic cell-cell communication regulates glandular stem cell multipotency.
Nature. 2020 Aug;584(7822):608-613. doi: 10.1038/s41586-020-2632-y.
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Mechanisms of stretch-mediated skin expansion at single-cell resolution.
Aragona M, Sifrim A, Malfait M, Song Y, Van Herck J, Dekoninck S, Gargouri S, Lapouge G, Swedlund B, Dubois C, Baatsen P, Vints K, Han S, Tissir F, Voet T, Simons BD, Blanpain C
Nature 2020 Jul 29. doi: 10.1038/s41586-020-2555-7
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Guidelines and definitions for research on epithelial-mesenchymal transition.
Nat Rev Mol Cell Biol. 2020 Jun;21(6):341-352. doi: 10.1038/s41580-020-0237-9. Epub 2020 Apr 16.PMID: 32300252 Free PMC article. Review.
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Novel Approach for Quantifying Cancer Cells Showing Hybrid Epithelial/ Mesenchymal States in Large Series of Tissue Samples: Towards a New Prognostic Marker.
Godin L, Balsat C, Van Eycke YR, Allard J, Royer C, Remmelink M, Pastushenko I, D’Haene N, Blanpain C, Salmon I, Rorive S, Decaestecker C.
Cancers (Basel). 2020 Apr 8;12(4). pii: E906. doi: 10.3390/cancers12040906
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Defining the design principles of postnatal tissue growth
Dekoninck S, Hannezo E, Aragona A, Sifrim A, Malfait M, Gargouri S, de Neunheuser C, Dubois C, Voet T, Simons Benjamin D, Blanpain C
Cell. 2020 Apr 5. pii: S0092-8674(20)30277-4. doi: 10.1016/j.cell.2020.03.015. [Epub ahead of print]
Cover article
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Epidermal autonomous VEGFA/Flt1/Nrp1 functions mediate psoriasis-like disease
Benhadou F, Glitzner E, Brisebarre A, Dubois C, Rozzi M, Paulissen C, del Marmol V, Sibilia M, Blanpain C
Sci Adv. 2020 Jan 8;6(2):eaax5849. doi: 10.1126/sciadv.aax5849. eCollection 2020 Jan.
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Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch.
Miro C, Di Cicco E, Ambrosio R, Mancino G, Di Girolamo D, Cicatiello AG, Sagliocchi S, Nappi A, De Stefano MA, Luongo C, Antonini D, Visconte F, Varricchio S, Ilardi G, Del Vecchio L, Staibano S, Boelen A, Blanpain C, Missero C, Salvatore D, Dentice M.
Nat Commun. 2019 Nov 27;10(1):5410. doi: 10.1038/s41467-019-13140-2
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Context Dependency of Epithelial-to-Mesenchymal Transition for Metastasis.
Revenco T, Nicodème A, Pastushenko I, Sznurkowska MK, Latil M, Sotiropoulou PA, Dubois C, Moers V, Lemaire S, de Maertelaer V & Blanpain C.
Cell Rep. 2019 Nov 5;29(6):1458-1468. doi: 10.1016/j.celrep.2019.09.081
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Spatiotemporal regulation of multipotency during prostate development.
Tika E, Ousset M., Dannau A, Blanpain C
Development 2019 Oct 23;146(20). doi: 10.1242/dev.180224
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EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner.
Amberg N, Sotiropoulou PA, Heller G, Lichtenberger BM, Holcmann M, Camurdanoglu B, Baykuscheva-Gentscheva T, Blanpain C, Sibilia M
iScience. 2019 May 31;15:243-256. doi: 10.1016/j.isci.2019.04.018. Epub 2019 Apr 17
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EMT Transition States during Tumor Progression and Metastasis.
Pastushenko I, Blanpain C.
Trends Cell Biol. 2019 Mar;29(3):212-226. doi: 10.1016/j.tcb.2018.12.001. Epub 2018 Dec 26. Review.
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Stem cell dynamics, migration and plasticity during wound healing.
Dekoninck S, Blanpain C.
Nat Cell Biol. 2019 Jan;21(1):18-24. doi: 10.1038/s41556-018-0237-6. Epub 2019 Jan 2. Review.
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Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance.
Gupta PB, Pastushenko I, Skibinski A, Blanpain C, Kuperwasser C.
Cell Stem Cell. 2019 Jan 3;24(1):65-78. doi: 10.1016/j.stem.2018.11.011. Epub 2018 Dec 13. Review.
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A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy.
Sánchez-Danés A, Larsimont JC, Liagre M, Muñoz-Couselo E, Lapouge G, Brisebarre A, Dubois , Suppa M, Sukumaran V, Del Marmol V, Tabernero J, Blanpain C.
Nature. 2018 Oct;562(7727):434-438. doi: 10.1038/s41586-018-0603-3. Epub 2018 Oct 8.
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YAP and TAZ are essential for basal and squamous cell carcinoma initiation
Debaugnies M, Sánchez-Danés A, Rorive S, Liagre M, Brisebarre A, Parent MA, Salmon I, and Blanpain C
EMBO Rep. 2018 Jun 6. pii: e45809. doi: 10.15252/embr.201845809.
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Deciphering the cells of origin of Squamous Cell Carcinomas
Sánchez-Danés A and Blanpain C
Nat Rev Cancer. 2018 May 30. doi: 10.1038/s41568-018-0024-5
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Early lineage segregation of multipotent embryonic mammary gland progenitors
Wuidart A, Sifrim A, Matsumura S, Fioramonti M, Brisebarre A, Brown D , Centonze A, Dannau A, Dubois C, Van Keymeulen A, Voet T, Blanpain C
Nat Cell Biol. 2018 Jun;20(6):666-676. doi: 10.1038/s41556-018-0095-2. Epub 2018 May 21. Cover article Highlighted by a news and views in Nature Cell Biology
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News & Views
Identification of the tumour transition states occurring during EMT
Pastushenko I, Brisebarre A, Sifrim A, Fioramonti M, Renvenco T, Boumahdi S, Van Keymeulen A, Brown D, Moers V, Lemaire S, De Clercq S, Minguijon E, Cédric Balsat C, Sokolow Y, Dubois C, de Cock F, Scozzaro S, Sopena F, Lanas A, D’Haene N, Salmon I, Marine JC, Voet T, Sotiropoulou P and Blanpain C
Nature. 2018 Apr;556(7702):463-468. doi: 10.1038/s41586-018-0040-3. Epub 2018 Apr 18. Highlighted by a news and views in Nature
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News & Views
Universality of clone dynamics during tissue development
Rulands S, Lescroart F, Chabab S, Hindley CJ, Prior N, Sznurkowska MK, Huch M, Philpott A, Blanpain C, and Simons BD
Nature Physics, 2018 May;14(5):469-474. doi: 10.1038/s41567-018-0055-6. Epub 2018 Feb 26. Cover article
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Cover
Defining the earliest step of cardiovascular lineage segregation during gastrulation by single cell RNA-seq
Lescroart F, Wang X, Lin X, Swedlund B, Gargouri S, Sànchez-Dànes A, Moignard V, Dubois C, Paulissen C, Kinston S, Göttgens B, Blanpain C
Science. 2018 Mar 9;359(6380):1177-1181. doi: 10.1126/science.aao4174. Epub 2018 Jan 25. Highlighted by perspectives in Science and Nature Reviews Cardiology.
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News & Views
Gene therapy: Transgenic stem cells replace skin.
Aragona M, Blanpain C.
Nature. 2017 Nov 16;551(7680):306-307. doi: 10.1038/nature24753
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Mouse Cutaneous Melanoma Induced by Mutant BRaf Arises from Expansion and Dedifferentiation of Mature Pigmented Melanocytes.
Köhler C, Nittner D, Rambow F, Radaelli E, Stanchi F, Vandamme N, Baggiolini A, Sommer L, Berx G, van den Oord JJ, Gerhardt H, Blanpain C & Marine JC
Cell Stem Cell. 2017 Nov 2;21(5):679-693.e6. doi: 10.1016/j.stem.2017.08.003. Epub 2017 Oct 12.
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Lineage-Restricted Mammary Stem Cells Sustain the Development, Homeostasis, and Regeneration of the Estrogen Receptor Positive Lineage.
Van Keymeulen A, Fioramonti M, Centonze A, Bouvencourt G, Achouri Y, Blanpain C.
Cell Rep. 2017 Aug 15;20(7):1525-1532. doi: 10.1016/j.celrep.2017.07.066.
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Identifying the niche controlling melanocyte differentiation
Zocco M, Blanpain C.
Genes Dev. 2017 Apr 15;31(8):721-723. doi: 10.1101/gad.300665.117.
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Defining stem cell dynamics and migration during wound healing in mouse skin epidermis
Aragona M, Dekoninck S, Rulands S, Lenglez S, Mascré M, Simons B, Blanpain C.
Nature Communications 2017 Mar 1;8:14684. doi: 10.1038/ncomms14684.
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Cell Type Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor Initiating Cells for Epithelial to Mesenchymal Transition.
Latil M, Nassar D, Beck B, Boumahdi S, Wang L, Brisebarre A, Dubois C, Nkusi E, Lenglez S, Checinska A,
Vercauteren Drubbel A, Devos M, Declercq W, Yi R, Blanpain C.
Cell Stem Cell. 2017 Feb 2;20(2):191-204.e5. doi: 10.1016/j.stem.2016.10.018. Epub 2016 Nov 23. Highlighted by a preview in Cell Stem Cell
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Maintaining hair follicle stem cell identity in a dish.
Sánchez-Danés A, Blanpain C.
EMBO J. 2017 Jan 17;36(2):132-134. doi: 10.15252/embj.201696051.
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Editorial Overview: The ins and outs of stem cells in differentiation, inflammation & disease.
Blanpain C, Wagner EF.
Curr Opin Cell Biol. 2016 Dec;43:iv-vi. doi: 10.1016/j.ceb.2016.10.004.
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Defining the clonal dynamics leading to mouse skin tumor initiation
Sánchez-Danés A, Hannezo E, Larsimont JC, Liagre M, Youssef KK, Simons B, Blanpain C.
Nature. 2016 Aug 18;536(7616):298-303. Epub 2016 Jul 8.
p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity.
Adriaens C, Standaert L, Barra J, Latil M, Verfaillie A, Kalev P, Boeckx B, Wijnhoven PW, Radaelli E, Vermi W, Leucci E, Lapouge G, Beck B, van den Oord J, Nakagawa S, Hirose T, Sablina AA, Lambrechts D, Aerts S, Blanpain C, Marine JC.
Nat Med. 2016. Jul 4 doi: 10.1038/nm.4135.
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Quantitative lineage tracing strategies to resolve multipotency in tissue specific stem cells
Wuidart A, Ousset M, Rulands S, D Simons BD, Van Keymeulen A, Blanpain C.
Genes Dev. 2016 Jun 1;30(11):1261-77. doi: 10.1101/gad.280057.116. Epub 2016 Jun 9. Cover article
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Mesp1 controls the speed, polarity, and directionality of cardiovascular progenitor migration.
Chiapparo G, Chabab S, Lescroart F, Li X, Paulissen C, Pitisci L, Bondue A, and Blanpain C. J Cell Biol. 2016 May 23;213(4):463-77. doi: 10.1083/jcb.201505082.
Epub 2016 May 16. Highlighted by a preview in Journal of Cell Biology
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News & Views
Stem Cells: Basic Concepts and Therapeutic Implications.
Nassar D, Blanpain C. Cancer
Annu Rev Pathol. 2016 May 23;11:47-76. doi: 10.1146/annurev-pathol 012615-044438.
PubMed | PDF
Uncovering the number and clonal dynamics of Mesp1 progenitors during heart morphogenesis.
Chabab S, Lescroart F, Rulands S, Mathiah N, Simons BD and Blanpain C.
Cell Reports 2016 Jan 5;14(1):1-10. doi: 10.1016/j.celrep.2015.12.013. Epub 2015 Dec 24.
PubMed | PDF
Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis.
Sercin O., Larsimont J.C., Karambelas A.E., Marthiens V., Moers V., Boeckx B., e Mercier M., Lambrechts D., Basto R., Blanpain C.
Nature Cell Biology, 2016 Jan;18(1):100-10. doi: 10.1038/ncb3270. Epub 2015 Nov 23.
PubMed | PDF
Reactivation of multipotency by oncogenic PIK3CA induces breast tumor heterogeneity.
Van Keymeulen A, Lee M.Y., Ousset M, Rorive S, Brohée S, Wuidart A, Bouvencourt G, Giraddi R, Dubois C, Salmon I, Sotiriou C, Phillips W.A., Blanpain C.
Nature 2015 Sep 3;525(7567):119-23. doi: 10.1038/nature14665. Epub 2015 Aug 12.
PubMed | PDF
Alizadeh AA, Aranda V, Bardelli A, Blanpain C, Bock C, Borowski C, Caldas C, Califano A, Doherty M, Elsner M, Esteller M, Fitzgerald R, Korbel JO, Lichter P, Mason CE, Navin N, Pe’er D, Polyak K, Roberts CW, Siu L, Snyder A, Stower H, Swanton C, Verhaak RG, Zenklusen JC, Zuber J, Zucman-Rossi J.
Toward understanding and exploiting tumor heterogeneity.
Nat Med. 2015 Aug;21(8):846-53. doi: 10.1038/nm.3915.
PubMed | PDF
Genomic landscape of carcinogen and gentically-induced mouse skin squamous cell carcinoma.
Nassar D, Latil M, Boeckx B, Lambrechts D, Blanpain C.
Nat Med. 2015 Aug;21(8):946-54. doi: 10.1038/nm.3878. Epub 2015 Jul 13.
PubMed | PDF
NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets.
Bouveret R, Waardenberg AJ, Schonrock N, Ramialison M, Doan T, de Jong D, Bondue A, Kaur G, Mohamed S, Fonoudi H, Chen CM, Wouters M, Bhattacharya S, Plachta N, Dunwoodie SL, Chapman G, Blanpain C, Harvey RP.
Elife. 2015 Jul 6;4. doi: 10.7554/eLife.06942.
PubMed | PDF
Clonal Dynamics Reveal Two Distinct Populations of Basal Cells in Slow-Turnover Airway Epithelium.
Watson JK, Rulands S, Wilkinson AC, Wuidart A, Ousset M, Van Keymeulen A, Göttgens B, Blanpain C, Simons BD, Rawlins EL.
Cell Rep. 2015 Jul 7;12(1):90-101. doi: 10.1016/j.celrep.2015.06.011. Epub 2015 Jun 25.
PubMed | PDF
Sox9 Controls Self-Renewal of Oncogene Targeted Cells and Links Tumor Initiation and Invasion.
Larsimont JC, Youssef KK, Sánchez-Danés A, Sukumaran V, Defrance M, Delatte B, Liagre M, Baatsen P, Marine JC, Lippens S, Guerin C, Del Marmol V, Vanderwinden JM, Fuks F, Blanpain C.
Cell Stem Cell. 2015 Jul 2;17(1):60-73. doi: 10.1016/j.stem.2015.05.008. Epub 2015 Jun 18.
PubMed | PDF
Different levels of Twist1 regulate skin tumor initiation, stemness, and progression.
Beck B, Lapouge G, Rorive S, Drogat B, Desaedelaere K, Delafaille S, Dubois C, Salmon I, Willekens K, Marine JC, Blanpain C.
Cell Stem Cell. 2015 Jan 8;16(1):67-79. doi: 10.1016/j.stem.2014.12.002.
PubMed | PDF
Cardiac Cell Lineages that Form the Heart.
Meilhac SM, Lescroart F, Blanpain C, Buckingham ME.
Cold Spring Harb Perspect Med. 2014 Sep 2;4(9). pii: a013888. doi: 10.1101/cshperspect.a013888. Review.
PubMed | PDF
Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development.
Lescroart F, Chabab S, Lin X, Rulands S, Paulissen C, Rodolosse A, Auer H, Achouri Y, Dubois C, Bondue A, Simons BD, Blanpain C.
Nat Cell Biol. 2014 Sep;16(9):829-40. doi: 10.1038/ncb3024. Epub 2014 Aug 24.
PubMed | PDF
Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration.
Blanpain C, Fuchs E.
Science. 2014 Jun 13;344(6189):1242281. doi: 10.1126/science.1242281. Epub 2014 Jun 12. Review.
PubMed | PDF
SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma.
Boumahdi S, Driessens G, Lapouge G, Rorive S, Nassar D, Le Mercier M, Delatte B, Caauwe A, Lenglez S, Nkusi E, Brohée S, Salmon I, Dubois C, del Marmol V, Fuks F, Beck B, Blanpain C.
Nature. 2014 Jul 10;511(7508):246-50. doi: 10.1038/nature13305. Epub 2014 Jun 8.
PubMed | PDF
Unravelling cancer stem cell potential.
Beck B, Blanpain C.
Nat Rev Cancer. 2013 Oct;13(10):727-38. doi: 10.1038/nrc3597.
PubMed | PDF
aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation.
Niessen MT, Scott J, Zielinski JG, Vorhagen S, Sotiropoulou PA, Blanpain C, Leitges M, Niessen CM.
J Cell Biol. 2013 Sep 16;202(6):887-900. doi: 10.1083/jcb.201307001. Epub 2013 Sep 9.
PubMed | PDF
Unravelling stem cell dynamics by lineage tracing.
Blanpain C, Simons BD.
Nat Rev Mol Cell Biol. 2013 Aug;14(8):489-502. doi: 10.1038/nrm3625.
Epub 2013 Jul 17. Review.
PubMed | PDF
The expression of Sox17 identifies and regulates haemogenic endothelium.
Clarke RL, Yzaguirre AD, Yashiro-Ohtani Y, Bondue A, Blanpain C, Pear WS, Speck NA, Keller G.
Nat Cell Biol. 2013 May;15(5):502-10. doi: 10.1038/ncb2724. Epub 2013 Apr 21.
PubMed | PDF
Tracing the cellular origin of cancer.
Blanpain C.
Nat Cell Biol. 2013 Feb;15(2):126-34. doi: 10.1038/ncb2657.
Epub 2013 Jan 20. Review.
PubMed | PDF
BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny.
Sotiropoulou PA, Karambelas AE, Debaugnies M, Candi A, Bouwman P, Moers V, Revenco T, Rocha AS, Sekiguchi K, Jonkers J, Blanpain C.
Genes Dev. 2013 Jan 1;27(1):39-51. doi: 10.1101/gad.206573.112. Epub 2012 Dec 27.
PubMed | PDF
366 days: Nature’s 10.
Heuer RD, Rosenzweig C, Steltzner A, Blanpain C, Iorns E, Wang J, Handelsman J, Gowers T, De Bernardinis B, Fouchier R.
Nature. 2012 Dec 20;492(7429):335-43. doi: 10.1038/492335a. No abstract available. Erratum in: Nature. 2013 Jan 10;493(7431):147.
PubMed | PDF
RNF4 is required for DNA double-strand break repair in vivo.
Vyas R, Kumar R, Clermont F, Helfricht A, Kalev P, Sotiropoulou P, Hendriks IA, Radaelli E, Hochepied T, Blanpain C, Sablina A, van Attikum H, Olsen JV, Jochemsen AG, Vertegaal AC, Marine JC.
Cell Death Differ. 2013 Mar;20(3):490-502. doi: 10.1038/cdd.2012.145. Epub 2012 Nov 30.
PubMed | PDF
Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness.
Lapouge G, Beck B, Nassar D, Dubois C, Dekoninck S, Blanpain C.
EMBO J. 2012 Dec 12;31(24):4563-75. doi: 10.1038/emboj.2012.312. Epub 2012 Nov 27.
PubMed | PDF | PDF (SI)
Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation.
Youssef KK, Lapouge G, Bouvrée K, Rorive S, Brohée S, Appelstein O, Larsimont JC, Sukumaran V, Van de Sande B, Pucci D, Dekoninck S, Berthe JV, Aerts S, Salmon I, del Marmol V, Blanpain C.
Nat Cell Biol. 2012 Dec;14(12):1282-94. doi: 10.1038/ncb2628. Epub 2012 Nov 25.
PubMed | PDF | PDF (SI)
Multipotent and unipotent progenitors contribute to prostate postnatal development.
Ousset M, Van Keymeulen A, Bouvencourt G, Sharma N, Achouri Y, Simons BD, Blanpain C.
Nat Cell Biol. 2012 Oct 14. doi: 10.1038/ncb2600. [Epub ahead of print]
PubMed | PDF
Epidermal development and homeostasis.
Nassar D, Blanpain C.
Semin Cell Dev Biol. 2012 Sep 24. pii: S1084-9521(12)00170-X. doi: 10.1016/j.semcdb.2012.09.005. [Epub ahead of print]
PubMed | PDF
Distinct contribution of stem and progenitor cells to epidermal maintenance.
Mascré G, Dekoninck S, Drogat B, Youssef KK, Broheé S, Sotiropoulou PA, Simons BD, Blanpain C.
Nature. 2012 Sep 13;489(7415):257-62.
PubMed | PDF | PDF (Supplementary Info)
Defining the mode of tumour growth by clonal analysis.
Driessens G, Beck B, Caauwe A, Simons BD, Blanpain C.
Nature. 2012 Aug 23;488(7412):527-30.
PubMed | PDF | PDF (Supplementary Info) | Preview
Lu CP, Polak L, Rocha AS, Pasolli HA, Chen SC, Sharma N, Blanpain C, Fuchs E.
Identification of stem cell populations in sweat glands and ducts reveals roles in homeostasis and wound repair.
Cell. 2012 Jul 6;150(1):136-50.
PubMed | PDF
Sotiropoulou PA, Blanpain C.
Development and homeostasis of the skin epidermis.
Cold Spring Harb Perspect Biol. 2012 Jul 1;4(7):a008383. doi: 10.1101/cshperspect.a008383.
PubMed | PDF
Stem cells assessed.
Blanpain C, Daley GQ, Hochedlinger K, Passegué E, Rossant J, Yamanaka S.
Nat Rev Mol Cell Biol. 2012 Jun 8;13(7):471-6. doi: 10.1038/nrm3371.
PubMed | PDF
Tracing epithelial stem cells during development, homeostasis, and repair.
Van Keymeulen A, Blanpain C.
J Cell Biol. 2012 May 28;197(5):575-84
PubMed | PDF
Mechanisms regulating epidermal stem cells.
Beck B, Blanpain C.
EMBO J. 2012 Mar 20. doi: 10.1038/emboj.2012.67. [Epub ahead of print]
PubMed | PDF
Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin.
van den Ameele J, Tiberi L, Bondue A, Paulissen C, Herpoel A, Iacovino M, Kyba M, Blanpain C, Vanderhaeghen P.
EMBO Rep. 2012 Mar 9;13(4):355-362. doi: 10.1038/embor.2012.23. [Epub ahead of print]
PubMed| PDF
A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours.
Beck B, Driessens G, Goossens S, Youssef KK, Kuchnio A, Caauwe A, Sotiropoulou PA, Loges S, Lapouge G, Candi A, Mascre G, Drogat B, Dekoninck S, Haigh JJ, Carmeliet P, Blanpain C.
Nature. 2011 Oct 19;478(7369):399-403. doi: 10.1038/nature10525.
PubMed | PDF | PDF (Supplementary Info) | Preview
Distinct stem cells contribute to mammary gland development and maintenance.
Van Keymeulen A, Rocha AS, Ousset M, Beck B, Bouvencourt G, Rock J, Sharma N, Dekoninck S, Blanpain C.
Nature. 2011 Oct 9. doi: 10.1038/nature10573. [Epub ahead of print]
PubMed | PDF | PDF (Supplementary Info)
Long live sox2: sox2 lasts a lifetime.
Driessens G, Blanpain C.
Cell Stem Cell. 2011 Oct 4;9(4):283-4.
PubMed | PDF
A blizzard of stem cells in Santa Fe.
Youssef KK, Blanpain C.
EMBO Rep. 2011 Jun;12(6):485-7. Epub 2011 May 13.
PubMed | PDF
Identifying the cellular origin of squamous skin tumors.
Lapouge G, Youssef KK, Vokaer B, Achouri Y, Michaux C, Sotiropoulou PA, Blanpain C.
Proc Natl Acad Sci U S A. 2011 May 3;108(18):7431-6.
Epub 2011 Apr 18.
PubMed | PDF | Preview
Bondue A, Tännler S, Chiapparo G, Chabab S, Ramialison M, Paulissen C, Beck B, Harvey R, Blanpain C.
Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation.
J Cell Biol. 2011 Mar 7;192(5):751-65.
PubMed | PDF
DNA damage response in adult stem cells: pathways and consequences.
Mandal PK, Blanpain C, Rossi DJ.
Nat Rev Mol Cell Biol. 2011 Mar;12(3):198-202. Epub 2011 Feb 9.
PubMed | PDF
DNA-damage response in tissue-specific and cancer stem cells.
Blanpain C, Mohrin M, Sotiropoulou PA, Passegué E.
Cell Stem Cell. 2011 Jan 7;8(1):16-29.
PubMed | PDF
Identification of basal cell carcinoma initiating cells
Kass Youssef K, Lapouge G, Van Keymeulen A, Blanpain C.
Med Sci (Paris). 2010 Dec;26(12):1020-2. PubMed
Bondue A, Blanpain C.
Mesp1: a key regulator of cardiovascular lineage commitment.
Circ Res. 2010 Dec 10;107(12):1414-27.
PubMed | PDF
Medical applications of epidermal stem cells.
Lapouge G, Blanpain C.
StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008 Nov 15.
PubMed | PDF
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death.
Sotiropoulou PA, Candi A, Mascré G, De Clercq S, Kass Youseff K, Lapouge G, Dahl E, Semeraro C, Denecker G, Marine JC and Blanpain C (2010).
Nat Cell Biol. 2010 Jun;12(6):572-82. Epub 2010 May 16.
PubMed | PDF | Preview
Stem cells: Skin regeneration and repair.
Blanpain C. (2010).
Nature, 2010 Apr 1;464(7289):686-7.
PubMed | PDF
Identification of the cell lineage at the origin of basocellular carcinoma.
Kass Youseff K., Van Keymeulen A., Lapouge G., Beck B., Achouri Y., Michaux C., Sotiropoulou P. and Blanpain C. (2010).
Nature Cell Biology, 2010 Mar;12(3):299-305. Epub 2010 Feb 14.
PubMed | PDF | F1000 Biology | F1000 Medicine | Cover
A dominant role of the hair follicle stem cell niche in regulating melanocyte stemness.
Blanpain C. and Sotiropoulou P. (2010).
Cell Stem Cell. 2010 Feb 5;6(2):95-6
PubMed | PDF
Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis.
Van Keymeulen A., Mascre G., Kass Youseff K., Harel I., Michaux C., De Geest N., Spalski C., Achouri Y., Bloch W., Hassan B.A. and Blanpain C. (2009).
Journal of Cell Biology, 2009, 187:91-100
PubMed | PDF | Preview | F1000 Biology | F1000 Medicine
Epidermal homeostasis: A balancing act of stem cells in the skin.
Blanpain, C. and Fuchs, E. (2009).
Nature Reviews Molecular and Cell Biology (3):207-17
PubMed | PDF]
The Majority of Multipotent Epidermal Stem Cells Do Not Protect Their Genome By Asymmetrical Chromosome Segregation.
Sotiropoulou, P., Candi, A. and Blanpain, C. (2008).
Stem Cells 26(11):2964-73
PubMed | PDF
Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification.
Bondue, A., Lapouge, G., Paulissen, C., Semeraro, C., Iacovino, M., Kyba, M. and Blanpain, C. (2008).
Cell Stem Cell 3(1):69-84
PubMed | PDF
p63: Revving up epithelial stem cells potential.
Blanpain, C. and Fuchs, E. (2007).
Nature Cell Biology 7:731-33
PubMed | PDF
Epithelial Stem Cells: Turning over New Leaves.
Blanpain, C., Horsley, V. and Fuchs, E. (2007).
Cell 128:445-58
PubMed | PDF
Impact of beta-catenin signaling pathway on stem cell differentiation in the skin.
Blanpain, C.
Med Sci (Paris). 2007 Jan;23(1):34-6.
PubMed
Canonical notch signaling functions as a commitment switch in the epidermal lineage.
Blanpain, C., Lowry, W.E., Pasolli, A. and Fuchs, E. (2006).
Genes Dev. 20:3022-35
PubMed | PDF
A distant upstream locus control region is critical for expression of the Kit receptor gene in mast cells.
Berrozpe, G., Agosti, V., Tucker, C., Blanpain, C., Manova, K. and Besmer, P. (2006).
Mol Cell Biol. 15:5850-60
PubMed
Epidermal stem cells of the skin.
Blanpain, C. and Fuchs E. (2006).
Annu Rev Cell Dev Biol. 22:339-73
PubMed | PDF
Defining the impact of -catenin/Tcf transactivation on epithelial stem cells.
Lowry, W.E.*, Blanpain, C.*, Nowak, J.A., Guasch, G., Lewis, L. and Fuchs, E. (2005).
Blanpain, C. and Lowry, W.E. contributed equally to this work.
Epub 2005 Jun 16 and Genes Dev. (13):1596-611
PubMed | PDF
Mutation of the DRY Motif Reveals Different Structural Requirements for the CC Chemokine Receptor 5-Mediated Signaling and Receptor Endocytosis.
Lagane, B., Ballet, S., Planchenault, T., Balabanian, K., Le Poul, E., Blanpain, C., Percherancier, Y., Staropoli, I., Vassart, G., Oppermann, M., Parmentier, M. and Bachelerie, F. (2005).
Mol Pharmacol. 67(6):1966-76
PubMed
Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche.
Blanpain, C., Lowry, W.E., Geoghegan, A., Polak, L. and Fuchs, E. (2004).
Cell 118(5):635-48
PubMed | PDF
Defining the epithelial stem cell niche in skin.
Guasch, G. and Blanpain, C. (2004).
Med Sci (Paris) 20(3):265-7
PubMed | PDF
Defining the epithelial stem cell niche in skin. Science 303:359-63
Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W.E., Rendl, M. and Fuchs, E. (2004).
PubMed
Serotonin 5-HT2B receptor loss of function mutation in a patient with fenfluramine-associated primary pulmonary hypertension.
Blanpain, C., Le Poul, E., Parma, J., Knoop, C., Detheux, M., Parmentier, M., Vassart, G. and Abramowicz, M. (2003).
Cardiovascular Research 60(3):518-28
PubMed
Specific Recruitment of Antigen-Presenting Cells by Chemerin, a Novel Processed Ligand from Human inflammatory Fluids.
Wittamer, V., Franssen, J.D., Vulcano, M., Mirjolet, J.F., Le Poul, E., Migeotte, I., Brezillon, S., Tyldesley, R., Blanpain, C., Detheux, M., Mantovani, A., Sozzani, S., Vassart, G., Parmentier, M. and Communi, D. (2003).
J. Exp. Med. 198(7):977-85
PubMed | PDF
G protein-dependent CCR5 signaling is not required for efficient infection of primary T lymphocytes and macrophages by R5 human immunodeficiency virus type 1 isolates.
Amara, A., Vidy, A., Boulla, G., Mollier, K., Garcia-Perez, J., Alcami, J., Blanpain, C., Parmentier, M., Virelizier, J.L., Charneau, P. and Arenzana-Seisdedos, F. (2003).
J Virol. (2003 Feb) 77(4):2550-8
PubMed | PDF
The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle.
Blanpain, C., Doranz, B.J., Bondue, A., Govaerts, C., De Leener, A., Vassart, G., Doms, R.W., Proudfoot, A., Parmentier, M. (2003).
Epub (2002 Dec 03) and J Biol Chem. (2003 Feb 14) 278(7):5179-87
PubMed | PDF
Characterization of the role of the N-loop of MIP-1 beta in CCR5 binding.
Bondue, A., Jao, S.C., Blanpain, C., Parmentier, M. and LiWang, P.J. (2002).
Biochemistry (2002 Nov 19) 41(46):13548-55
PubMed | PDF
Govaerts, C., Bondue, A., Springael, J.Y., Olivella, M., Deupi, X., Le Poul, E., Wodak, S.J, Parmentier, M., Pardo, L.,Blanpain, C. (2003).
Aromatic residues in helices 2 and 3 of CCR5 are involved in chemokine-induced receptor activation.
Epub (2002 Oct 30) and J Biol Chem. (2003 Jan 17) 278(3):1892-903
PubMed | PDF
CCR5 and HIV infection
Blanpain, C., Libert, F., Vassart, G. and Parmentier, M. (2002).
Receptors and channels. 8: 19-31.
PubMed
Constitutive agonist-independent CCR5 oligomerization and antibody-mediated clustering occurring at physiological levels of receptors.
Issafras, H., Angers, S., Bulenger, S., Blanpain, C., Parmentier, M., Labbe-Jullie, C., Bouvier, M., Marullo, S. (2002).
J Biol Chem 277: 34666-34673
PubMed | PDF
Multiple active states and oligomerization of CCR5 revealed by the functional properties of monoclonal antibodies.
Blanpain, C., Vanderwinden, J.M., Cihak, J., Wittamer, V., Le Poul, E., Issafras, H., Stangassinger, M., Vassart, G., Marullo, S., Schlndorff, D., Parmentier, M. and Mack, M. (2002).
Mol. Biol. Cell 13: 723-737
PubMed | PDF
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
Kotani, M., Detheux, M., Vandenbogaerde, A., Communi, D., Vanderwinden, J.M., Le Poul, E., Brezillon, S., Tyldesley, R., Suarez-Huerta, N., Vandeput, F., Blanpain, C., Schiffmann, S.N., Vassart, G., Parmentier, M. (2001).=
J Biol Chem 276:34631-6
PubMed
A chimeric MIP-1 /RANTES protein demonstrates the use of different regions of the RANTES protein to bind and activate its receptors.
Blanpain, C., Buser, R., Power, C.A., Edgerton, M., Buchanan, C., Mack, M., Simmons, G., Clapham, P.R., Parmentier, M. and Proudfoot, A.E. (2001).
J. Leuk. Biol. 69:977-985
PubMed
Palmitoylation of CCR5 is critical for receptor trafficking and efficient activation of intracellular signaling pathways.
Blanpain, C., Wittamer, V., Vanderwinden, J.M., Boom, A., Renneboog, B., Lee, B., Le Poul, E., El Asmar, L., Govaerts, C., Vassart, G., Doms, R.W., Parmentier, M. (2001).
J Biol Chem. 276:23795-23804
PubMed | PDF
Structural and functional analysis of the RANTES-glycosaminoglycans interactions.
Martin, L.*, Blanpain, C.*, Garnier, P., Wittamer, V., Parmentier, M. and Vita, C. (2001). Blanpain, C. and Martin, L. contributed equally to this work.
Biochemistry 40:6303-18
PubMed
The Importance of Basic Residues and Quaternary Structure in the Function of MIP-1 : CCR5 Binding and Cell Surface Sugar Interactions.
Laurence, J.S., Blanpain, C., De Leener, A., Parmentier, M. and LiWang, P.J. (2001).
Biochemistry 40:4990-9
PubMed | PDF
The Txp motif in the second transmembrane helix of CCR5 : a structural determinant of chemokine-induced activation.
Govaerts, C.*, Blanpain, C.*, Deupi, X., Ballet, S., Ballesteros, J.A., Wodak, S.J., Vassart, G., Pardo, L. and Parmentier, M. (2001). Blanpain, C. and Govaerts, C. contributed equally to this work.
J Biol Chem. 276:13217-25
PubMed | PDF
Multiple nonfunctional alleles of CCR5 are frequent in various human populations.
Blanpain, C., Lee, B., Tackoen, M., Puffer, B., Boom, A., Libert, F., Sharron, M., Wittamer, V., Vassart, G., Doms, R.W. and Parmentier, M. (2000).
Blood 96:1638-45
PubMed | PDF
CC chemokine MIP-1 beta can function as a monomer and depends on Phe13 for receptor binding.
Laurence, J.S., Blanpain, C., Burgner, J.W., Parmentier, M. and LiWang, P.J. (2000).
Biochemistry 39:3401-9
PubMed
Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein.
Blanpain, C., Doranz, B.J., Vakili, J., Rucker, J., Govaerts, C., Baik, S.S., Lorthioir, O., Migeotte, I., Libert, F., Baleux, F., Vassart, G., Doms, R.W. and Parmentier, M. (1999).
J Biol Chem. 274:34719-27
PubMed | PDF
CCR5 Binds Multiple CC-Chemokines: MCP-3 Acts as a Natural Antagonist.
Blanpain, C., Migeotte, I., Lee, B., Vakili, J., Doranz, B.J., Govaerts, C., Vassart, G., Doms, R.W. and Parmentier, M. (1999).
Blood (1999 Sep 15) 94(6):1899-1905
PubMed | PDF
Extracellular cysteines of CCR5 are required for chemokinebinding, but dispensable for HIV-1 coreceptor activity.
Blanpain, C., Lee, B., Vakili, J., Doranz, B.J., Govaerts, C., Migeotte, I., Sharron, M., Dupriez, V., Vassart, G., Doms, R.W. and Parmentier, M. (1999).
J Biol Chem 274:18902-8
PubMed | PDF
Functional dissection of CCR5 coreceptor function through the use of CD4-independent simian immunodeficiency virus strains.
Edinger, A.L., Blanpain, C., Kunstman, K.J., Wolinsky, S.M., Parmentier, M., Doms, R.W. (1999).
J Virol 73:4062-73
PubMed
Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function.
Lee, B., Sharron, M., Blanpain, C., Doranz, B.J., Vakili, J., Setoh, P., Berg, E., Liu, G., Guy, H.R., Durell, S.R., Parmentier, M., Chang, C.N., Price, K., Tsang, M. and Doms, R.W. (1999).
J Biol Chem 274:9617-26
PubMed
Reactivation of hepatitis B after transplantation in patients with pre-existing anti-hepatitis B surface antigen antibodies: report on three cases and review of the literature.
Blanpain, C., Knoop, C., Delforge, M.L., Antoine, M., Peny, M.O., Liesnard, C., Vereerstraeten, P., Cogan, E., Adler, M. and Abramowicz, D. (1998).
Transplantation 66:883-6
PubMed
Hepatitis B virus infection.
Abramowicz, D., Blanpain, C. and Knoop, C. (1998).
N Engl J Med 338:1311-2
PubMed