Publications

Our Papers

Ousset M, Van Keymeulen A, Bouvencourt G, Sharma N, Achouri Y, Simons BD, Blanpain C.
Multipotent and unipotent progenitors contribute to prostate postnatal development.
Nat Cell Biol. 2012 Oct 14. doi: 10.1038/ncb2600. [Epub ahead of print]
PubMed | PDF

Nassar D, Blanpain C.
Epidermal development and homeostasis.
Semin Cell Dev Biol. 2012 Sep 24. pii: S1084-9521(12)00170-X. doi: 10.1016/j.semcdb.2012.09.005. [Epub ahead of print]
PubMed | PDF

Mascré G, Dekoninck S, Drogat B, Youssef KK, Broheé S, Sotiropoulou PA, Simons BD, Blanpain C.
Distinct contribution of stem and progenitor cells to epidermal maintenance.
Nature. 2012 Sep 13;489(7415):257-62.
PubMed | PDF | PDF (Supplementary Info)

Driessens G, Beck B, Caauwe A, Simons BD, Blanpain C.
Defining the mode of tumour growth by clonal analysis.
Nature. 2012 Aug 23;488(7412):527-30.
PubMed | PDF | PDF (Supplementary Info) | Preview

Lu CP, Polak L, Rocha AS, Pasolli HA, Chen SC, Sharma N, Blanpain C, Fuchs E.
Identification of stem cell populations in sweat glands and ducts reveals roles in homeostasis and wound repair.
Cell. 2012 Jul 6;150(1):136-50.
PubMed | PDF

Sotiropoulou PA, Blanpain C.
Development and homeostasis of the skin epidermis.
Cold Spring Harb Perspect Biol. 2012 Jul 1;4(7):a008383. doi: 10.1101/cshperspect.a008383.
PubMed | PDF

Blanpain C, Daley GQ, Hochedlinger K, Passegué E, Rossant J, Yamanaka S.
Stem cells assessed.
Nat Rev Mol Cell Biol. 2012 Jun 8;13(7):471-6. doi: 10.1038/nrm3371.
PubMed | PDF

Van Keymeulen A, Blanpain C.
Tracing epithelial stem cells during development, homeostasis, and repair.
J Cell Biol. 2012 May 28;197(5):575-84
PubMed | PDF

Beck B, Blanpain C.
Mechanisms regulating epidermal stem cells.
EMBO J. 2012 Mar 20. doi: 10.1038/emboj.2012.67. [Epub ahead of print]
PubMed | PDF

van den Ameele J, Tiberi L, Bondue A, Paulissen C, Herpoel A, Iacovino M, Kyba M, Blanpain C, Vanderhaeghen P.
Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin.
EMBO Rep. 2012 Mar 9;13(4):355-362. doi: 10.1038/embor.2012.23. [Epub ahead of print]
PubMed| PDF

Beck B, Driessens G, Goossens S, Youssef KK, Kuchnio A, Caauwe A, Sotiropoulou PA, Loges S, Lapouge G, Candi A, Mascre G, Drogat B, Dekoninck S, Haigh JJ, Carmeliet P, Blanpain C.
A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours.
Nature. 2011 Oct 19;478(7369):399-403. doi: 10.1038/nature10525.
PubMed | PDF | PDF (Supplementary Info) | Preview

Van Keymeulen A, Rocha AS, Ousset M, Beck B, Bouvencourt G, Rock J, Sharma N, Dekoninck S, Blanpain C.
Distinct stem cells contribute to mammary gland development and maintenance.
Nature. 2011 Oct 9. doi: 10.1038/nature10573. [Epub ahead of print]
PubMed | PDF | PDF (Supplementary Info)

Driessens G, Blanpain C.
Long live sox2: sox2 lasts a lifetime.
Cell Stem Cell. 2011 Oct 4;9(4):283-4.
PubMed | PDF

Youssef KK, Blanpain C.
A blizzard of stem cells in Santa Fe.
EMBO Rep. 2011 Jun;12(6):485-7. Epub 2011 May 13.
PubMed | PDF

Lapouge G, Youssef KK, Vokaer B, Achouri Y, Michaux C, Sotiropoulou PA, Blanpain C.
Identifying the cellular origin of squamous skin tumors.
Proc Natl Acad Sci U S A. 2011 May 3;108(18):7431-6. Epub 2011 Apr 18.
PubMed | PDF | Preview

Bondue A, Tännler S, Chiapparo G, Chabab S, Ramialison M, Paulissen C, Beck B, Harvey R, Blanpain C.
Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation.
J Cell Biol. 2011 Mar 7;192(5):751-65.
PubMed | PDF

Mandal PK, Blanpain C, Rossi DJ.
DNA damage response in adult stem cells: pathways and consequences.
Nat Rev Mol Cell Biol. 2011 Mar;12(3):198-202. Epub 2011 Feb 9.
PubMed | PDF

Blanpain C, Mohrin M, Sotiropoulou PA, Passegué E.
DNA-damage response in tissue-specific and cancer stem cells.
Cell Stem Cell. 2011 Jan 7;8(1):16-29.
PubMed | PDF

Kass Youssef K, Lapouge G, Van Keymeulen A, Blanpain C.
Identification of basal cell carcinoma initiating cells
Med Sci (Paris). 2010 Dec;26(12):1020-2.
PubMed

Bondue A, Blanpain C.
Mesp1: a key regulator of cardiovascular lineage commitment.
Circ Res. 2010 Dec 10;107(12):1414-27.
PubMed | PDF

Lapouge G, Blanpain C.
Medical applications of epidermal stem cells.
StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008 Nov 15.
PubMed | PDF

Sotiropoulou PA, Candi A, Mascré G, De Clercq S, Kass Youseff K, Lapouge G, Dahl E, Semeraro C, Denecker G, Marine JC and Blanpain C (2010).
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death.
Nat Cell Biol. 2010 Jun;12(6):572-82. Epub 2010 May 16.
PubMed | PDF | Preview

Blanpain C. (2010).
Stem cells: Skin regeneration and repair.
Nature, 2010 Apr 1;464(7289):686-7.
PubMed | PDF

Kass Youseff K., Van Keymeulen A., Lapouge G., Beck B., Achouri Y., Michaux C., Sotiropoulou P. and Blanpain C. (2010).
Identification of the cell lineage at the origin of basocellular carcinoma.
Nature Cell Biology, 2010 Mar;12(3):299-305. Epub 2010 Feb 14.
PubMed | PDF | F1000 Biology | F1000 Medicine

Blanpain C. and Sotiropoulou P. (2010).
A dominant role of the hair follicle stem cell niche in regulating melanocyte stemness.
Cell Stem Cell. 2010 Feb 5;6(2):95-6
PubMed | PDF

Van Keymeulen A., Mascre G., Kass Youseff K., Harel I., Michaux C., De Geest N., Spalski C., Achouri Y., Bloch W., Hassan B.A. and Blanpain C. (2009).
Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis.
Journal of Cell Biology, 2009, 187:91-100
PubMed | PDF | Preview | F1000 Biology | F1000 Medicine

Blanpain, C. and Fuchs, E. (2009).
Epidermal homeostasis: A balancing act of stem cells in the skin.
Nature Reviews Molecular and Cell Biology (3):207-17
PubMed | PDF

Sotiropoulou, P., Candi, A. and Blanpain, C. (2008).
The Majority of Multipotent Epidermal Stem Cells Do Not Protect Their Genome By Asymmetrical Chromosome Segregation.
Stem Cells 26(11):2964-73
PubMed | PDF

Bondue, A., Lapouge, G., Paulissen, C., Semeraro, C., Iacovino, M., Kyba, M. and Blanpain, C. (2008).
Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification.
Cell Stem Cell 3(1):69-84
PubMed | PDF

Blanpain, C. and Fuchs, E. (2007).
p63: Revving up epithelial stem cells potential.
Nature Cell Biology 7:731-33
PubMed | PDF

Blanpain, C., Horsley, V. and Fuchs, E. (2007).
Epithelial Stem Cells: Turning over New Leaves.
Cell 128:445-58
PubMed | PDF

Blanpain, C..
Impact of beta-catenin signaling pathway on stem cell differentiation in the skin.
Med Sci (Paris). 2007 Jan;23(1):34-6.
PubMed

Blanpain, C., Lowry, W.E., Pasolli, A. and Fuchs, E. (2006).
Canonical notch signaling functions as a commitment switch in the epidermal lineage.
Genes Dev. 20:3022-35
PubMed | PDF

Berrozpe, G., Agosti, V., Tucker, C., Blanpain, C., Manova, K. and Besmer, P. (2006).
A distant upstream locus control region is critical for expression of the Kit receptor gene in mast cells.
Mol Cell Biol. 15:5850-60
PubMed

Blanpain, C. and Fuchs E. (2006).
Epidermal stem cells of the skin.
Annu Rev Cell Dev Biol. 22:339-73
PubMed | PDF

Lowry, W.E.*, Blanpain, C.*, Nowak, J.A., Guasch, G., Lewis, L. and Fuchs, E. (2005). Blanpain, C. and Lowry, W.E. contributed equally to this work.
Defining the impact of -catenin/Tcf transactivation on epithelial stem cells.
Epub 2005 Jun 16 and Genes Dev. (13):1596-611
PubMed | PDF

Lagane, B., Ballet, S., Planchenault, T., Balabanian, K., Le Poul, E., Blanpain, C., Percherancier, Y., Staropoli, I., Vassart, G., Oppermann, M., Parmentier, M. and Bachelerie, F. (2005).
Mutation of the DRY Motif Reveals Different Structural Requirements for the CC Chemokine Receptor 5-Mediated Signaling and Receptor Endocytosis.
Mol Pharmacol. 67(6):1966-76
PubMed

Blanpain, C., Lowry, W.E., Geoghegan, A., Polak, L. and Fuchs, E. (2004).
Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche.
Cell 118(5):635-48
PubMed | PDF

Guasch, G. and Blanpain, C. (2004).
Defining the epithelial stem cell niche in skin.
Med Sci (Paris) 20(3):265-7
PubMed | PDF

Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W.E., Rendl, M. and Fuchs, E. (2004).
Defining the epithelial stem cell niche in skin.
Science 303:359-63
PubMed

Blanpain, C., Le Poul, E., Parma, J., Knoop, C., Detheux, M., Parmentier, M., Vassart, G. and Abramowicz, M. (2003).
Serotonin 5-HT2B receptor loss of function mutation in a patient with fenfluramine-associated primary pulmonary hypertension.
Cardiovascular Research 60(3):518-28
PubMed

Wittamer, V., Franssen, J.D., Vulcano, M., Mirjolet, J.F., Le Poul, E., Migeotte, I., Brezillon, S., Tyldesley, R., Blanpain, C., Detheux, M., Mantovani, A., Sozzani, S., Vassart, G., Parmentier, M. and Communi, D. (2003).
Specific Recruitment of Antigen-Presenting Cells by Chemerin, a Novel Processed Ligand from Human inflammatory Fluids.
J. Exp. Med. 198(7):977-85
PubMed | PDF

Amara, A., Vidy, A., Boulla, G., Mollier, K., Garcia-Perez, J., Alcami, J., Blanpain, C., Parmentier, M., Virelizier, J.L., Charneau, P. and Arenzana-Seisdedos, F. (2003).
G protein-dependent CCR5 signaling is not required for efficient infection of primary T lymphocytes and macrophages by R5 human immunodeficiency virus type 1 isolates.
J Virol. (2003 Feb) 77(4):2550-8
PubMed | PDF

Blanpain, C., Doranz, B.J., Bondue, A., Govaerts, C., De Leener, A., Vassart, G., Doms, R.W., Proudfoot, A., Parmentier, M. (2003).
The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle.
Epub (2002 Dec 03) and J Biol Chem. (2003 Feb 14) 278(7):5179-87
PubMed | PDF

Bondue, A., Jao, S.C., Blanpain, C., Parmentier, M. and LiWang, P.J. (2002).
Characterization of the role of the N-loop of MIP-1 beta in CCR5 binding.
Biochemistry (2002 Nov 19) 41(46):13548-55
PubMed | PDF

Govaerts, C., Bondue, A., Springael, J.Y., Olivella, M., Deupi, X., Le Poul, E., Wodak, S.J, Parmentier, M., Pardo, L.,Blanpain, C. (2003).
Aromatic residues in helices 2 and 3 of CCR5 are involved in chemokine-induced receptor activation.
Epub (2002 Oct 30) and J Biol Chem. (2003 Jan 17) 278(3):1892-903
PubMed | PDF

Blanpain, C., Libert, F., Vassart, G. and Parmentier, M. (2002).
CCR5 and HIV infection Receptors and channels.
8: 19-31.
PubMed

Issafras, H., Angers, S., Bulenger, S., Blanpain, C., Parmentier, M., Labbe-Jullie, C., Bouvier, M., Marullo, S. (2002).
Constitutive agonist-independent CCR5 oligomerization and antibody-mediated clustering occurring at physiological levels of receptors.
J Biol Chem 277: 34666-34673
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Blanpain, C., Vanderwinden, J.M., Cihak, J., Wittamer, V., Le Poul, E., Issafras, H., Stangassinger, M., Vassart, G., Marullo, S., Schlndorff, D., Parmentier, M. and Mack, M. (2002).
Multiple active states and oligomerization of CCR5 revealed by the functional properties of monoclonal antibodies.
Mol. Biol. Cell 13: 723-737
PubMed | PDF

Kotani, M., Detheux, M., Vandenbogaerde, A., Communi, D., Vanderwinden, J.M., Le Poul, E., Brezillon, S., Tyldesley, R., Suarez-Huerta, N., Vandeput, F., Blanpain, C., Schiffmann, S.N., Vassart, G., Parmentier, M. (2001).
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
J Biol Chem 276:34631-6
PubMed

Blanpain, C., Buser, R., Power, C.A., Edgerton, M., Buchanan, C., Mack, M., Simmons, G., Clapham, P.R., Parmentier, M. and Proudfoot, A.E. (2001).
A chimeric MIP-1 /RANTES protein demonstrates the use of different regions of the RANTES protein to bind and activate its receptors.
J. Leuk. Biol. 69:977-985
PubMed

Blanpain, C., Wittamer, V., Vanderwinden, J.M., Boom, A., Renneboog, B., Lee, B., Le Poul, E., El Asmar, L., Govaerts, C., Vassart, G., Doms, R.W., Parmentier, M. (2001).
Palmitoylation of CCR5 is critical for receptor trafficking and efficient activation of intracellular signaling pathways.
J Biol Chem. 276:23795-23804
PubMed | PDF

Martin, L.*, Blanpain, C.*, Garnier, P., Wittamer, V., Parmentier, M. and Vita, C. (2001). Blanpain, C. and Martin, L. contributed equally to this work.
Structural and functional analysis of the RANTES-glycosaminoglycans interactions.
Biochemistry 40:6303-18
PubMed

Laurence, J.S., Blanpain, C., De Leener, A., Parmentier, M. and LiWang, P.J. (2001).
The Importance of Basic Residues and Quaternary Structure in the Function of MIP-1 : CCR5 Binding and Cell Surface Sugar Interactions.
Biochemistry 40:4990-9
PubMed | PDF

Govaerts, C.*, Blanpain, C.*, Deupi, X., Ballet, S., Ballesteros, J.A., Wodak, S.J., Vassart, G., Pardo, L. and Parmentier, M. (2001). Blanpain, C. and Govaerts, C. contributed equally to this work.
The Txp motif in the second transmembrane helix of CCR5 : a structural determinant of chemokine-induced activation.
J Biol Chem. 276:13217-25
PubMed | PDF

Blanpain, C., Lee, B., Tackoen, M., Puffer, B., Boom, A., Libert, F., Sharron, M., Wittamer, V., Vassart, G., Doms, R.W. and Parmentier, M. (2000).
Multiple nonfunctional alleles of CCR5 are frequent in various human populations.
Blood 96:1638-45
PubMed | PDF

Laurence, J.S., Blanpain, C., Burgner, J.W., Parmentier, M. and LiWang, P.J. (2000).
CC chemokine MIP-1 beta can function as a monomer and depends on Phe13 for receptor binding.
Biochemistry 39:3401-9
PubMed

Blanpain, C., Doranz, B.J., Vakili, J., Rucker, J., Govaerts, C., Baik, S.S., Lorthioir, O., Migeotte, I., Libert, F., Baleux, F., Vassart, G., Doms, R.W. and Parmentier, M. (1999).
Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein.
J Biol Chem. 274:34719-27
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Blanpain, C., Migeotte, I., Lee, B., Vakili, J., Doranz, B.J., Govaerts, C., Vassart, G., Doms, R.W. and Parmentier, M. (1999).
CCR5 Binds Multiple CC-Chemokines: MCP-3 Acts as a Natural Antagonist.
Blood (1999 Sep 15) 94(6):1899-1905
PubMed | PDF

Blanpain, C., Lee, B., Vakili, J., Doranz, B.J., Govaerts, C., Migeotte, I., Sharron, M., Dupriez, V., Vassart, G., Doms, R.W. and Parmentier, M. (1999).
Extracellular cysteines of CCR5 are required for chemokinebinding, but dispensable for HIV-1 coreceptor activity.
J Biol Chem 274:18902-8
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Edinger, A.L., Blanpain, C., Kunstman, K.J., Wolinsky, S.M., Parmentier, M., Doms, R.W. (1999).
Functional dissection of CCR5 coreceptor function through the use of CD4-independent simian immunodeficiency virus strains.
J Virol 73:4062-73
PubMed

Lee, B., Sharron, M., Blanpain, C., Doranz, B.J., Vakili, J., Setoh, P., Berg, E., Liu, G., Guy, H.R., Durell, S.R., Parmentier, M., Chang, C.N., Price, K., Tsang, M. and Doms, R.W. (1999).
Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function.
J Biol Chem 274:9617-26
PubMed

Blanpain, C., Knoop, C., Delforge, M.L., Antoine, M., Peny, M.O., Liesnard, C., Vereerstraeten, P., Cogan, E., Adler, M. and Abramowicz, D. (1998).
Reactivation of hepatitis B after transplantation in patients with pre-existing anti-hepatitis B surface antigen antibodies: report on three cases and review of the literature.
Transplantation 66:883-6
PubMed

Abramowicz, D., Blanpain, C. and Knoop, C. (1998).
Hepatitis B virus infection.
N Engl J Med 338:1311-2
PubMed

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